0001104659-23-097162 Sample Contracts

AMENDMENT NO. 1
Deposit Agreement • August 31st, 2023 • JPMorgan Chase Bank, N.A. - ADR Depositary • American depositary receipts

AMENDMENT NO. 1, dated as of March 2, 2017 (the "Amendment"), to the Amended and Restated Deposit Agreement dated as of August 11, 2010 (the "Deposit Agreement") among NOVO NORDISK A/S, incorporated under the laws of Denmark (herein called the "Company"), JPMORGAN CHASE BANK, N.A., a national banking association organized under the laws of the United States, in its capacity as Depositary hereunder (herein called the "Depositary"), and all holders from time to time of American Depositary Shares issued thereunder.

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Contract
Deposit Agreement • August 31st, 2023 • JPMorgan Chase Bank, N.A. - ADR Depositary • American depositary receipts • New York

AMENDMENT NO. 2, dated as of ___________________ __, 2023 (the “Amendment”), to the Amended and Restated Deposit Agreement, dated as of August 11, 2010, as amended by Amendment No. 1, dated as of March 2, 2017 (as previously amended, the “Deposit Agreement”, among NOVO NORDISK A/S, a company incorporated under the laws of Denmark, and its successors (the “Company”), JPMORGAN CHASE BANK, N.A., a national banking association organized under the laws of the United States of America, as depositary hereunder (in such capacity, the “Depositary”), and all holders from time to time of American Depositary Receipts (“ADRs”) issued thereunder.

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