0001104659-24-029417 Sample Contracts

RHYTHM PHARMACEUTICALS, Inc. Common Stock AMENDMENT NO. 1 TO SALES AGREEMENT
Sales Agreement • February 29th, 2024 • Rhythm Pharmaceuticals, Inc. • Pharmaceutical preparations • New York

Reference is made to the Sales Agreement, dated November 2, 2021 (the “Agreement”), by and between Rhythm Pharmaceuticals, Inc., a Delaware corporation (the “Company”), and Cowen and Company, LLC (“Cowen”). The Company and Cowen (collectively, the “Parties”) wish to amend the Agreement, pursuant to Section 15 of the Agreement, to increase the aggregate offering price under the Agreement (this “Amendment”). The Parties therefore hereby agree as follows:

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