0001104659-24-038925 Sample Contracts

TO LICENSE, DEVELOPMENT AND COMMERCIALIZATION AGREEMENT
License, Development and Commercialization Agreement • March 26th, 2024 • Acura Pharmaceuticals, Inc • Pharmaceutical preparations • New York

This AMENDMENT #8 (this "Amendment") TO LICENSE, DEVELOPMENT AND COMMERCIALIZATION AGREEMENT (the "Agreement") dated June 28, 2019 between Acura Pharmaceuticals, Inc. ("Acura"), a New York corporation, having a place of business at 616 N. North Court, Suite 120, Palatine, IL 60067, and Abuse Deterrent Pharma, LLC ("AD Pharma"), a Kentucky limited liability company, having a place of business at 333 E. Main Street, Suite 220, Louisville, Kentucky 40202, is made as of March 15, 2024.

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AMENDED, CONSOLIDATED AND RESTATED SECURED PROMISSORY NOTE
Secured Promissory Note • March 26th, 2024 • Acura Pharmaceuticals, Inc • Pharmaceutical preparations

This AMENDMENT #2 (this “Amendment”) TO AMENDED, CONSOLIDATED AND RESTATED SECURED PROMISSSORY NOTE (the “Note”) dated November 10, 2022 between Acura Pharmaceuticals, Inc. (“Acura”), a New York corporation, having a place of business at 616 N. North Court, Suite 120, Palatine, IL 60067, and Abuse Deterrent Pharma, LLC (“AD Pharma”), a Kentucky limited liability company, having a place of business at 333 E. Main Street, Suite 220, Louisville, Kentucky 40202, is made as of March 15, 2024.

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