0001113481-12-000025 Sample Contracts

AG SUPPLY AGREEMENT BY AND AMONG THE MEDICINES COMPANY AND APP PHARMACEUTICALS, LLC DATED AS OF JANUARY 22, 2012
Ag Supply Agreement • May 10th, 2012 • Medicines Co /De • Pharmaceutical preparations • Delaware

THIS AG SUPPLY AGREEMENT (this “Agreement”) is entered into as of January 22, 2012 (the “Effective Date”) by and between, on the one hand The Medicines Company, a company organized and existing under the laws of the State of Delaware with offices located at 8 Sylvan Way, Parsippany, New Jersey 07054 and its Affiliates (collectively, “MDCO”), and, on the other hand, APP Pharmaceuticals, LLC, a limited liability company organized and existing under the laws of the State of Delaware with offices at 1501 East Woodfield Road, Suite 300 East, Schaumburg, Illinois 60173 and its Affiliates (collectively, “APP”). MDCO and APP are collectively referred to herein as the “Parties,” or each individually as a “Party.”

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Contract Manufacturing Agreement
Contract Manufacturing Agreement • May 10th, 2012 • Medicines Co /De • Pharmaceutical preparations • Delaware

WHEREAS, MDCO wishes to have the Product manufactured, packaged, tested, and supplied to it by APP for commercial sales, and APP wishes to manufacture, package, test and supply to MDCO the Product for commercial sales, in accordance with the terms and conditions of this Agreement; and

LICENSE AND SUPPLY AGREEMENT
License and Supply Agreement • May 10th, 2012 • Medicines Co /De • Pharmaceutical preparations • Delaware

This License and Supply Agreement (this “Agreement”) is entered into as of the 22nd day of January, 2012 (the “Effective Date”), by and between The Medicines Company, a corporation organized and existing under the laws of the State of Delaware, having a place of business at 8 Sylvan Way, Parsippany, New Jersey 07054 (“MDCO”), and on the other hand, APP Pharmaceuticals, LLC, a limited liability company organized and existing under the laws of the State of Delaware, having a place of business at 1501 East Woodfield Road, Suite 300 East, Schaumburg, Illinois 60173 (“APP”). MDCO and APP are collectively referred to herein as “Parties,” or each separately, as a “Party.”

LICENSE AGREEMENT BY AND AMONG THE MEDICINES COMPANY AND APP PHARMACEUTICALS, LLC AND APP PHARMACEUTICALS, INC. DATED AS OF JANUARY 22, 2012
License Agreement • May 10th, 2012 • Medicines Co /De • Pharmaceutical preparations • Delaware

THIS LICENSE AGREEMENT (this “Agreement”) is entered into as of January 22, 2012 (the “Effective Date”) by and between, on the one hand The Medicines Company, a company organized and existing under the laws of the State of Delaware with offices located at 8 Sylvan Way, Parsippany, New Jersey 07054 and its Affiliates (collectively, “MDCO”), and, on the other hand, APP Pharmaceuticals, LLC, a limited liability company organized and existing under the laws of the State of Delaware with offices at 1501 East Woodfield Road, Suite 300 East, Schaumburg, Illinois 60173 and its Affiliates, and APP Pharmaceuticals, Inc., a corporation organized and existing under the laws of the State of Delaware with offices at 1501 East Woodfield Road, Suite 300 East, Schaumburg, Illinois 60173 and its Affiliates, (collectively, “APP”). MDCO and APP are collectively referred to herein as the “Parties,” or each individually as a “Party.”

SETTLEMENT AGREEMENT BY AND AMONG THE MEDICINES COMPANY AND APP PHARMACEUTICALS, LLC AND APP PHARMACEUTICALS, INC. DATED AS OF JANUARY 22, 2012
Settlement Agreement • May 10th, 2012 • Medicines Co /De • Pharmaceutical preparations • Delaware

THIS SETTLEMENT AGREEMENT, (this “Settlement Agreement”) is entered into as of January 22, 2012 (the “Effective Date”) by and between, on the one hand, The Medicines Company, a company organized and existing under the laws of the State of Delaware with offices located at 8 Sylvan Way, Parsippany, New Jersey 07054 and its Affiliates (collectively “MDCO”), and, on the other hand, APP Pharmaceuticals, LLC, a limited liability company organized and existing under the laws of the State of Delaware with offices at 1501 East Woodfield Road, Suite 300 East, Schaumburg, Illinois 60173 and its Affiliates, and APP Pharmaceuticals, Inc., a corporation organized and existing under the laws of the State of Delaware with offices at 1501 East Woodfield Road, Suite 300 East, Schaumburg, Illinois 60173 and its Affiliates, (collectively, “APP”). MDCO and APP are collectively referred to herein as the “Parties,” or each individually as a “Party.”

AMENDMENT NO. 1 TO SUPPLY AGREEMENT By and between Teva API, Inc. and The Medicines Company
Supply Agreement • May 10th, 2012 • Medicines Co /De • Pharmaceutical preparations

THIS AMENDMENT NO. 1 (“First Amendment”) to the Supply Agreement, as defined below, is made and entered into as of February 13, 2012 (the “Effective Date”) by and between Teva API, Inc. (formerly known as Plantex USA Inc.), a New Jersey corporation with offices at 400 Chestnut Ridge Road, Woodcliff Lake, NJ 07670 (“TEVA”) and The Medicines Company, a Delaware corporation with offices at 8 Sylvan Way, Parsippany, NJ 07054 (“MDCO”). TEVA and MDCO are sometimes together referred to herein as the “Parties” and separately as a “Party.”

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