0001113481-14-000016 Sample Contracts

FIRST AMENDMENT TO GLOBAL COLLABORATION AGREEMENT

Global Collaboration Agreement • March 3rd, 2014 • Medicines Co /De • Pharmaceutical preparations

• Contract Type
  Global Collaboration Agreement
• Filed
  March 3rd, 2014
• Company
  Medicines Co /De
• Industry
  Pharmaceutical preparations

THIS FIRST AMENDMENT TO GLOBAL COLLABORATION AGREEMENT (this “Amendment”) is made and entered into as of the 24th day of July, 2012 (the “Amendment Effective Date”), by and between AstraZeneca LP, a Delaware limited partnership (“AstraZeneca”), and The Medicines Company, a Delaware corporation (“MDCO”).

Confidential Materials omitted and filed separately with the Securities and Exchange Commission. Double asterisks denote omissions. SECOND AMENDMENT TO GLOBAL COLLABORATION AGREEMENT

Global Collaboration Agreement • March 3rd, 2014 • Medicines Co /De • Pharmaceutical preparations

• Contract Type
  Global Collaboration Agreement
• Filed
  March 3rd, 2014
• Company
  Medicines Co /De
• Industry
  Pharmaceutical preparations

THIS SECOND AMENDMENT TO GLOBAL COLLABORATION AGREEMENT (this “Second Amendment”) is made and entered into as of the ___ day of December, 2013 (the “Second Amendment Effective Date”), by and between AstraZeneca LP, a Delaware limited partnership (“AstraZeneca”), and The Medicines Company, a Delaware corporation (“MDCO”).