0001113481-18-000041 Sample Contracts

Confidential Materials omitted and filed separately with the Securities and Exchange Commission. Triple asterisks denote omissions TENTH AMENDMENT TO SECOND AMENDED AND RESTATED DISTRIBUTION AGREEMENT
Distribution Agreement • August 2nd, 2018 • Medicines Co /De • Pharmaceutical preparations

This Tenth Amendment to Second Amended and Restated Distribution Agreement (this “Amendment”) is between The Medicines Company, a Delaware corporation with offices at 8 Sylvan Way, Parsippany, NJ 07054 (“MDCO”), and Integrated Commercialization Solutions, LLC, f/k/a Integrated Commercialization Solutions, Inc., a California limited liability company with offices at 3101 Gaylord Parkway, Frisco, TX 75034 (“Distributor”). This Amendment is effective as of April 30, 2018 (the “Amendment Effective Date”). MDCO and Distributor shall, at times throughout this Amendment, be referred to individually as a “Party” and collectively as the “Parties”.

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THE MEDICINES COMPANY Form of Non-statutory Stock Option Agreement Granted Under 2013 Stock Incentive Plan
Medicines Co /De • August 2nd, 2018 • Pharmaceutical preparations
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