0001121702-19-000090 Sample Contracts

12,480,000 SHARES OF COMMON STOCK, 2,504 SHARES OF SERIES A CONVERTIBLE PREFERRED STOCK (CONVERTIBLE INTO 12,520,000 SHARES OF COMMON STOCK), WARRANTS EXERCISABLE INTO 50,000,000 SHARES OF COMMON STOCK OF YIELD10 BIOSCIENCE, INC. UNDERWRITING AGREEMENT
Underwriting Agreement • November 20th, 2019 • Yield10 Bioscience, Inc. • Miscellaneous plastics products • New York

The undersigned, Yield10 Bioscience, Inc., a company incorporated under the laws of Delaware (collectively with its subsidiaries and affiliates, including, without limitation, all entities disclosed or described in the Registration Statement as being subsidiaries or affiliates of Yield10 Bioscience, Inc., the “Company”), hereby confirms its agreement (this “Agreement”) with the several underwriters (such underwriters, including the Representative (as defined below), the “Underwriters” and each an “Underwriter”) named in Schedule I hereto for which Ladenburg Thalmann & Co. Inc. is acting as representative to the several Underwriters (the “Representative” and if there are no Underwriters other than the Representative, references to multiple Underwriters shall be disregarded and the term Representative as used herein shall have the same meaning as Underwriter) on the terms and conditions set forth herein.

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SECURITIES PURCHASE AGREEMENT
Securities Purchase Agreement • November 20th, 2019 • Yield10 Bioscience, Inc. • Miscellaneous plastics products • Delaware

This SECURITIES PURCHASE AGREEMENT (this “Agreement”) dated November 14, 2019, is entered into by and among (i) Yield10 Bioscience, Inc., a Delaware corporation (the “Company”), and (ii) each person listed on Schedule I hereto (each, an “Investor” and collectively, the “Investors”).

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