0001125282-03-002354 Sample Contracts

NPS Pharmaceuticals, Inc. 420 Chipeta Way Salt Lake City, Utah 84108 RE: Amendment Agreement to Amend the November 26, 1997 Amendment Agreement Dear Sirs:
NPS Pharmaceuticals Inc • March 21st, 2003 • Biological products, (no disgnostic substances)

This Amendment Agreement to Amend the November 26, 1997 Amendment Agreement (hereinafter “January 24, 2000 Amendment Agreement”) will confirm that the Letter Agreement dated November 26, 1997 between NPS Pharmaceuticals, Inc., a corporation of the state of Delaware, having a place of business at 420 Chipeta Way, Salt Lake City, Utah 84108, U.S.A. (herein referred to as “NPS”) and SmithKline Beecham Corporation, a corporation of the Commonwealth of Pennsylvania, having a place of business at One Franklin Plaza, Philadelphia, Pennsylvania 19101, U.S.A. (hereinafter referred to as “SB”) shall be amended, effective as of the date of NPS' signature below, as follows:

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AMENDMENT TO LEASE – EXPANSION
NPS Pharmaceuticals Inc • March 21st, 2003 • Biological products, (no disgnostic substances)

THIS AMENDMENT is executed at Salt Lake City, Utah between Salt Lake Research Park Associates a New Mexico Limited Partnership by BGK Realty Inc, a Delaware Corporation, as General Partner, Landlord, and NPS Pharmaceuticals, Inc., a Delaware Corporation, Tenant, for the premises located at 420 Chipeta Way Suite 240, Salt Lake City, Utah 84108.

FOURTH AMENDMENT TO LEASE
Lease • March 21st, 2003 • NPS Pharmaceuticals Inc • Biological products, (no disgnostic substances)

THIS FOURTH AMENDMENT TO LEASE dated this 22 day of September, 1998, by and between Salt Lake Research Associates, LP, a New Mexico Limited Partnership, hereinafter referred to as Landlord, and NPS Pharmaceuticals Inc., a Delaware Corporation, hereinafter referred to as Tenant, for premises located at 420 Chipeta Way, Suites 20200 and 20240; and premises located at 410 Chipeta Way, Suite 10219, Salt Lake City, Utah 84108.

THIRD AMENDMENT TO LEASE – EXPANSION
NPS Pharmaceuticals Inc • March 21st, 2003 • Biological products, (no disgnostic substances)

THIS THIRD AMENDMENT is executed at Salt Lake City, Utah between Salt Lake Research Park Associates, a New Mexico Limited Partnership, by BGK Realty. Inc, a Delaware Corporation, as General Partner, Landlord, and NPS Pharmaceuticals, Inc., a Delaware Corporation, Tenant, for the premises located at 420 Chipeta Way, Suites 140, 200 & 202 Salt Lake Citv, Utah 84108.

AMENDMENT TO LEASE – EXPANSION
NPS Pharmaceuticals Inc • March 21st, 2003 • Biological products, (no disgnostic substances)

THIS AMENDMENT is executed at Salt Lake City, Utah between Salt Lake Research Park Associates, a New Mexico Limited Partnership, by BGK Realty, Inc., a Delaware Corporation, as General Partner, Landlord, and NPS Pharmaceuticals, Inc.. a Delaware Corporation., Tenant, for the premises located at 420 Chipeta Way, Suites 140, 200 & 202 Salt Lake City, Utah 84108.

Contract
1999 Patent Agreement • March 21st, 2003 • NPS Pharmaceuticals Inc • Biological products, (no disgnostic substances)

Effective February 18, 1999, The Brigham and Women's Hospital, Inc., a Massachusetts not-for-profit corporation having its principal offices at 75 Francis Street, Boston, Massachusetts 02115 (the “Hospital”), and NPS Pharmaceuticals, Inc., a Delaware corporation having its principal offices at 420 Chipeta Way, Salt Lake City, Utah 84108 (the “Company”) agree as follows:

NPS Pharmaceuticals, Inc. 420 Chipeta Way Salt Lake City, Utah 84108 RE: Amendment Agreement to Amend the January 24, 2000 Amendment Agreement Dear Sirs:
NPS Pharmaceuticals Inc • March 21st, 2003 • Biological products, (no disgnostic substances)

This Amendment Agreement to amend the January 24, 2000 Amendment Agreement will confirm that the Letter Agreement dated November 26, 1997 between NPS Pharmaceuticals, Inc., a corporation of the state of Delaware, having a place of business at 420 Chipeta Way, Salt Lake City, Utah 84108, U.S.A. (herein referred to as “NPS”) and SmithKline Beecham Corporation, a GlaxoSmithKline Company, a corporation of the Commonwealth of Pennsylvania, having a place of business at One Franklin Plaza, Philadelphia, Pennsylvania 19101, U.S.A. (hereinafter referred to as “GSK”) shall be amended, effective as of the date of NPS’ signature below, as follows:

FIFTH AMENDMENT TO LEASE
Lease • March 21st, 2003 • NPS Pharmaceuticals Inc • Biological products, (no disgnostic substances)

THIS FIFTH AMENDMENT TO LEASE dated this 14 day of April, 1999, by and between Salt Lake Research Associates, LP, a New Mexico Limited Partnership, hereinafter referred to as Landlord, and NPS Pharmaceuticals Inc., a Delaware Corporation, hereinafter referred to as Tenant, for premises located at 420 Chipeta Way, Suites 20200 and 20240; and premises located at 410 Chipeta Way, Suite 10219, Salt Lake City, Utah 84108.

NPS Pharmaceuticals, Inc. 420 Chipeta Way Salt Lake City, Utah 84108 RE: Amendment Agreement Dear Sirs:
Amendment Agreement • March 21st, 2003 • NPS Pharmaceuticals Inc • Biological products, (no disgnostic substances)

This Amendment Agreement (hereinafter “Amendment Agreement”) will confirm that the November 1, 1993 Collaborative Research and License Agreement between NPS Pharmaceuticals, Inc., a corporation of the state of Delaware, having a place of business at 420 Chipeta Way, Salt Lake City, Utah 84108, U.S.A. (herein referred to as “NPS”) and SmithKline Beecham Corporation, a corporation of the Commonwealth of Pennsylvania, having a place of business at One Franklin Plaza, Philadelphia, Pennsylvania 19101, U.S.A. (hereinafter referred to as “SB”) as amended (hereinafter collectively referred to as “Original Agreement”) shall be further amended as follows:

RE: Letter Agreement for Patent Agreement Dated February 19, 1993
NPS Pharmaceuticals Inc • March 21st, 2003 • Biological products, (no disgnostic substances)

NPS and the Hospital have found that the executed Patent Agreement contained a typographical error in the paragraph which appears therein as paragraph 5. C. As executed, that paragraph reads as follows:

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