0001140361-16-046574 Sample Contracts

AMENDMENT NO. 1 TO LOAN DOCUMENTS
Loan Amendment • January 5th, 2016 • Ionis Pharmaceuticals Inc • Pharmaceutical preparations

This Amendment No. 1 to Loan Documents (the “Amendment”), dated as of December 30, 2015, is made by and between IONIS PHARMACEUTICALS, INC., f/k/a ISIS PHARMACEUTICALS, INC. (the “Borrower”), and MORGAN STANLEY PRIVATE BANK, NATIONAL ASSOCIATION, a national banking association (the “Lender”).

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