0001140361-18-013588 Sample Contracts

LICENSE AGREEMENT

And License Agreement • March 15th, 2018 • Akcea Therapeutics, Inc. • Pharmaceutical preparations • New York

• Contract Type
  And License Agreement
• Filed
  March 15th, 2018
• Company
  Akcea Therapeutics, Inc.
• Industry
  Pharmaceutical preparations
• Jurisdiction
  New York

THIS DEVELOPMENT, COMMERCIALIZATION, COLLABORATION, AND LICENSE AGREEMENT is made and entered into as of March 14, 2018 (the “Execution Date”), by and between Akcea Therapeutics, Inc., a Delaware corporation (“Akcea”), and Ionis Pharmaceuticals, Inc., a Delaware corporation (“Ionis”). Akcea and Ionis each may be referred to herein individually as a “Party,” or collectively as the “Parties.”

AKCEA THERAPEUTICS, INC. AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT March 14, 2018

Investor Rights Agreement • March 15th, 2018 • Akcea Therapeutics, Inc. • Pharmaceutical preparations

• Contract Type
  Investor Rights Agreement
• Filed
  March 15th, 2018
• Company
  Akcea Therapeutics, Inc.
• Industry
  Pharmaceutical preparations

THIS INVESTOR RIGHTS AGREEMENT (this “Agreement”) is entered into as of March 14, 2018 between Akcea Therapeutics Inc., a Delaware corporation (“Akcea” or the “Company”), and Ionis Pharmaceuticals, Inc., a Delaware corporation (“Ionis” or “Investor”).