0001140361-19-000397 Sample Contracts

SECOND AMENDMENT AGREEMENT
Second Amendment Agreement • January 4th, 2019 • Apricus Biosciences, Inc. • Pharmaceutical preparations • New York

SECOND AMENDMENT AGREEMENT, dated as of January 4, 2019 (this "Agreement"), by and among Seelos Therapeutics, Inc., a Delaware corporation, ("Seelos"), Apricus Biosciences, Inc., a Nevada corporation ("Apricus"), and the investor listed on the signature pages attached hereto (the "Investor"). All terms used and not defined herein are used as defined in the Securities Purchase Agreement and the Warrants (each as defined below), as applicable.

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