0001140361-19-001204 Sample Contracts

THIRD AMENDMENT AGREEMENT
Third Amendment Agreement • January 16th, 2019 • Apricus Biosciences, Inc. • Pharmaceutical preparations • New York

THIRD AMENDMENT AGREEMENT, dated as of January 16, 2019 (this "Agreement"), by and among Seelos Therapeutics, Inc., a Delaware corporation, ("Seelos"), Apricus Biosciences, Inc., a Nevada corporation ("Apricus"), and the investor listed on the signature pages attached hereto (the "Investor"). All terms used and not defined herein are used as defined in the Securities Purchase Agreement and the Warrants (each as defined below), as applicable.

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AMENDMENT NO. 3 AGREEMENT AND PLAN OF MERGER AND REORGANIZATION
Agreement and Plan of Merger and Reorganization • January 16th, 2019 • Apricus Biosciences, Inc. • Pharmaceutical preparations • Delaware

This Amendment No. 3 to Agreement and Plan of Merger and Reorganization (this “Amendment”), is made and entered into as of January 16, 2019, by and among Apricus Biosciences, Inc., a Nevada corporation (“Apricus”), Arch Merger Sub, Inc., a Delaware corporation and wholly owned subsidiary of Apricus (“Merger Sub”), and Seelos Therapeutics, Inc., a Delaware corporation (the “Company”). Capitalized terms used herein and not otherwise defined shall have the meanings assigned to such terms in that certain Agreement and Plan of Merger and Reorganization, made and entered as of July 30, 2018, by and among Apricus, Merger Sub and the Company (the “Merger Agreement”).

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