0001140361-19-009024 Sample Contracts

LOAN AND SECURITY AGREEMENT
Loan and Security Agreement • May 14th, 2019 • Castle Biosciences Inc • Services-medical laboratories

THIS LOAN AND SECURITY AGREEMENT (as the same may from time to time be amended, modified, supplemented or restated, this “Agreement”) dated as of November 30, 2018 (the “Effective Date”) among OXFORD FINANCE LLC, a Delaware limited liability company with an office located at 133 North Fairfax Street, Alexandria, Virginia 22314 (“Oxford”), as collateral agent (in such capacity, “Collateral Agent”), the Lenders listed on Schedule 1.1 hereof or otherwise a party hereto from time to time including Oxford in its capacity as a Lender and SILICON VALLEY BANK, a California corporation with an office located at 3003 Tasman Drive, Santa Clara, CA 95054 (“Bank” or “SVB”) (each a “Lender” and collectively, the “Lenders”), and CASTLE BIOSCIENCES, INC., a Delaware Corporation with offices located at 820 South Friendswood Drive, Suite 201, Friendswood, TX 77546 (“Borrower”), provides the terms on which the Lenders shall lend to Borrower and Borrower shall repay the Lenders. The parties agree as follo

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CASTLE BIOSCIENCES, INC.
Stock Option Agreement • May 14th, 2019 • Castle Biosciences Inc • Services-medical laboratories • Delaware

Unless otherwise defined herein, the terms defined in the 2008 Stock Plan (the “Plan”) shall have the same defined meanings in this Stock Option Agreement (the “Option Agreement”).

Contract
Castle Biosciences Inc • May 14th, 2019 • Services-medical laboratories • California

THIS WARRANT AND THE SHARES ISSUABLE HEREUNDER HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “ACT”), OR THE SECURITIES LAWS OF ANY STATE AND, EXCEPT AS SET FORTH IN SECTIONS 5.3 AND 5.4 BELOW, MAY NOT BE OFFERED, SOLD, PLEDGED OR OTHERWISE TRANSFERRED UNLESS AND UNTIL REGISTERED UNDER SAID ACT AND APPLICABLE STATE SECURITIES LAWS OR, IN THE OPINION OF LEGAL COUNSEL IN FORM AND SUBSTANCE SATISFACTORY TO THE COMPANY, SUCH OFFER, SALE, PLEDGE OR OTHER TRANSFER IS EXEMPT FROM SUCH REGISTRATION.

Contract
Castle Biosciences Inc • May 14th, 2019 • Services-medical laboratories • California

THIS WARRANT AND THE SHARES ISSUABLE HEREUNDER HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “ACT”), OR THE SECURITIES LAWS OF ANY STATE AND, EXCEPT AS SET FORTH IN SECTIONS 5.3 AND 5.4 BELOW, MAY NOT BE OFFERED, SOLD, PLEDGED OR OTHERWISE TRANSFERRED UNLESS AND UNTIL REGISTERED UNDER SAID ACT AND APPLICABLE STATE SECURITIES LAWS OR, IN THE OPINION OF LEGAL COUNSEL IN FORM AND SUBSTANCE SATISFACTORY TO THE COMPANY, SUCH OFFER, SALE, PLEDGE OR OTHER TRANSFER IS EXEMPT FROM SUCH REGISTRATION.

Contract
Castle Biosciences Inc • May 14th, 2019 • Services-medical laboratories • California

THIS WARRANT AND THE SHARES ISSUABLE HEREUNDER HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “ACT”), OR THE SECURITIES LAWS OF ANY STATE AND, EXCEPT AS SET FORTH IN SECTIONS 5.3 AND 5.4 BELOW, MAY NOT BE OFFERED, SOLD, PLEDGED OR OTHERWISE TRANSFERRED UNLESS AND UNTIL REGISTERED UNDER SAID ACT AND LAWS OR, IN THE OPINION OF LEGAL COUNSEL IN FORM AND SUBSTANCE SATISFACTORY TO THE COMPANY, SUCH OFFER, SALE, PLEDGE OR OTHER TRANSFER IS EXEMPT FROM SUCH REGISTRATION.

STANDARD OFFICE LEASE BY AND BETWEEN MERCED RESTART PHOENIX INVESTORS II, LLC, A DELAWARE LIMIT ED LIABILITY COMPANY AS LANDLORD, AND CASTLE BIOSCIENCES, INC., A DELAWARE CORPORATION AS TENANT 3737 N. 7TH STREET, PHOENIX, ARIZONA SUITE 160
Office Lease • May 14th, 2019 • Castle Biosciences Inc • Services-medical laboratories • Arizona

This Standard Office Lease (“Lease”) is made and entered into and effective as of this this 5th day of October, 201 5, b y and between Merced Restart Phoenix Investors II, LLC. a Delaware limited liability company (“Landlord”), and Castle Biosciences, Inc., a Delaware corporation (“Tenant”).

CASTLE BIOSCIENCES, INC. FIFTH AMENDED AND RESTATED INVESTORS’ RIGHTS AGREEMENT July 15, 2015
Investors’ Rights Agreement • May 14th, 2019 • Castle Biosciences Inc • Services-medical laboratories • Delaware

This Fifth Amended and Restated Investors’ Rights Agreement (this “Agreement”) is dated as of July 15, 2015, and is between Castle Biosciences, Inc., a Delaware corporation (the “Company”), and the persons and entities listed on Exhibit A hereto (each, an “Investor” and collectively, the “Investors”). This Agreement amends and restates that certain Fourth Amended and Restated Investors’ Rights Agreement dated August 11, 2014 (the “Prior Agreement”), by and between the Company and certain of the Investors. Unless otherwise defined herein, capitalized terms used in this Agreement have the meanings ascribed to them in Section 1.

Contract
Castle Biosciences Inc • May 14th, 2019 • Services-medical laboratories • California

THIS WARRANT AND THE SHARES ISSUABLE HEREUNDER HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “ACT”), OR THE SECURITIES LAWS OF ANY STATE AND, EXCEPT AS SET FORTH IN SECTIONS 5.3 AND 5.4 BELOW, MAY NOT BE OFFERED, SOLD, PLEDGED OR OTHERWISE TRANSFERRED UNLESS AND UNTIL REGISTERED UNDER SAID ACT AND LAWS OR, IN THE OPINION OF LEGAL COUNSEL IN FORM AND SUBSTANCE SATISFACTORY TO THE COMPANY, SUCH OFFER, SALE, PLEDGE OR OTHER TRANSFER IS EXEMPT FROM SUCH REGISTRATION.

EXCLUSIVE LICENSE AGREEMENT
Exclusive License Agreement • May 14th, 2019 • Castle Biosciences Inc • Services-medical laboratories • Missouri

THIS LICENSE AGREEMENT (“Agreement”) is made and entered into as of this 14th day of November, 2009 (“Effective Date”) by and between The Washington University, a corporation established by special act of the Missouri General Assembly, approved February 22, 1853 and acts amendatory thereto, having its principal office at One Brookings Drive, St. Louis, Missouri 63130 (“WUSTL”), and Castle Biosciences, Inc., a corporation, (“Licensee”) having a principal office at 2014 San Miguel Drive, Friendswood, Texas 77546 and the following correspondence address:

OFFICE BUILDING LEASE
Office Building Lease • May 14th, 2019 • Castle Biosciences Inc • Services-medical laboratories
Re: Directorship
Letter Agreement • May 14th, 2019 • Castle Biosciences Inc • Services-medical laboratories

On behalf of Castle Biosciences, Inc. (the “Company”), I thank you for agreeing to be a member of the Company’s Board of Directors (the “Board”). The Company looks forward to your expertise as it grows and strives to bring substantial value to its stakeholders. This letter agreement (this “Agreement’) confirms the understanding and agreement between you and the Company with respect to your role as a director of the Company (a “Director”).

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