0001140361-20-030055 Sample Contracts

Ionis Pharmaceuticals, Inc. GLOBAL OPTION AGREEMENT (INCENTIVE STOCK OPTION OR NONSTATUTORY STOCK OPTION)
Global Option Agreement • December 31st, 2020 • Ionis Pharmaceuticals Inc • Pharmaceutical preparations • Delaware

Pursuant to your Option Grant Notice (“Grant Notice”) and this Global Option Agreement, including all appendices hereto (this “Agreement”), Ionis Pharmaceuticals, Inc. (the “Company”) has granted you an option under its 2020 Equity Incentive Plan (the “Plan”) to purchase the number of shares of the Company’s Common Stock (the “Option”) indicated in your Grant Notice at the exercise price indicated in your Grant Notice. Defined terms not explicitly defined in this Agreement but defined in the Plan shall have the same definitions as in the Plan, or in the Grant Notice, as applicable.

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Ionis Pharmaceuticals, Inc. Global Restricted Stock Unit Agreement
Global Restricted Stock Unit Agreement • December 31st, 2020 • Ionis Pharmaceuticals Inc • Pharmaceutical preparations • California

Pursuant to the Restricted Stock Unit Grant Notice (“Grant Notice”) and this Global Restricted Stock Unit Agreement, including any appendices thereto (the “Agreement”), Ionis Pharmaceuticals, Inc. (the “Company”) has awarded you a Restricted Stock Unit Award (the “Award”) under its 2020 Equity Incentive Plan (the “Plan”). Your Award is granted to you effective as of the Date of Grant set forth in the Grant Notice for this Award. If not otherwise accepted by you, this Agreement shall be deemed to be agreed to by the Company and you upon the earlier of (i) signing (or electronic acceptance) by you of the Restricted Stock Unit Grant Notice to which it is attached, and (ii) your receipt of shares of Common Stock under this Agreement. Capitalized terms not explicitly defined in this Agreement shall have the same meanings given to them in the Plan or the Grant Notice, as applicable. In the event of any conflict between the terms in this Agreement and the Plan, the terms of the Plan shall con

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