0001140361-24-009930 Sample Contracts

AMENDMENT TO INITIAL REGISTERED NOTE
Initial Registered Note • February 28th, 2024 • Bionano Genomics, Inc. • Laboratory analytical instruments

This AMENDMENT TO INITIAL REGISTERED NOTE (this “Amendment”), dated February 27, 2024, is entered into by and among Bionano Genomics, Inc., a Delaware corporation, (the “Company”), and the investor listed on the Schedule of Buyers (the “Buyer”) attached to the Purchase Agreement (defined below). The Company and the Buyer each may be hereinafter referred to as a “Party” and together as the “Parties.”

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HIGH TRAIL CAPITAL LP Hoboken, NJ 07030
Bionano Genomics, Inc. • February 28th, 2024 • Laboratory analytical instruments

Reference is made to that certain Securities Purchase Agreement (the “Securities Purchase Agreement”), dated as of October 11, 2023, by and between Bionano Genomics, Inc., a Delaware corporation (the “Company”), and High Trail Special Situations LLC (the “Holder”) pursuant to which the Company issued (i) $45,000,000 in aggregate principal amount of Initial Registered Notes and (ii) $35,000,000 in aggregate principal amount of Initial Private Placement Notes. Terms used but not defined herein shall have the meaning ascribed to them in the Securities Purchase Agreement.

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