0001140361-24-024935 Sample Contracts

ICON INVESTMENTS SIX DESIGNATED ACTIVITY COMPANY, ICON PLC, EACH OF THE SUBSIDIARY GUARANTORS FROM TIME TO TIME PARTY HERETO, Citibank, N.A., as Trustee,
First Supplemental Indenture • May 8th, 2024 • Icon PLC • Services-commercial physical & biological research • Dublin

FIRST SUPPLEMENTAL INDENTURE, dated as of May 8, 2024 (this “First Supplemental Indenture”), among ICON INVESTMENTS SIX DESIGNATED ACTIVITY COMPANY, a designated activity company limited by shares in Ireland (the “Issuer”), ICON PUBLIC LIMITED COMPANY, a public limited company in Ireland (the “Parent”), the guarantors from time to time party hereto (together with the Parent, the “Guarantors”), Citibank, N.A., a national banking association, as Trustee, Paying Agent and Registrar and CITIBANK, N.A., LONDON BRANCH, as notes collateral agent (in such capacity, the “Notes Collateral Agent”).

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