0001144204-05-019799 Sample Contracts

CONTINUING UNCONDITIONAL SECURED GUARANTY
Continuing Unconditional Secured Guaranty • June 23rd, 2005 • Acura Pharmaceuticals, Inc • Pharmaceutical preparations • New York

This Continuing Unconditional Secured Guaranty (“Guaranty”) is made as of June 22, 2005 by Axiom Pharmaceutical Corporation, a Delaware corporation (“Guarantor”) in favor of Galen Partners III, L.P., a Delaware limited partnership, acting in its capacity as agent for the Lenders, as defined below (“Agent”), for the benefit of the Lenders.

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LOAN AGREEMENT
Loan Agreement • June 23rd, 2005 • Acura Pharmaceuticals, Inc • Pharmaceutical preparations • New York

This Loan Agreement (“Agreement”) is made as of June 22, 2005 by and among (i) Acura Pharmaceuticals, Inc., a New York corporation (“Company”), (ii) Essex Woodlands Health Ventures V, L.P. (“Essex”), (iii) Care Capital Investments II, L.P. and Care Capital Offshore Investments II, L.P. (collectively “Care Capital”) and (iv) Galen Partners III, L.P., Galen Partners International III, L.P. and Galen Employee Fund III, L.P. (collectively “Galen and, together with Essex and Care Capital, the “Lenders”). In consideration of the mutual covenants contained in this Agreement and other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, the parties hereby agree as follows:

STOCK PLEDGE AGREEMENT
Stock Pledge Agreement • June 23rd, 2005 • Acura Pharmaceuticals, Inc • Pharmaceutical preparations • New York

This Stock Pledge Agreement (this “Agreement”) is dated as of June 22, 2005 by and between Acura Pharmaceuticals, Inc., a New York corporation (the “Pledgor”), and Galen Partners III, L.P., a Delaware limited partnership, acting in its capacity as agent for the Lenders, as hereinafter defined (the “Agent”), for the benefit of the Lenders.

GUARANTORS GENERAL SECURITY AGREEMENT
General Security Agreement • June 23rd, 2005 • Acura Pharmaceuticals, Inc • Pharmaceutical preparations • New York

This Guarantors General Security Agreement (the “Agreement”) is dated as of June 22, 2005 by and among Acura Pharmaceutical Technologies, Inc., an Indiana corporation with its principal place of business at 16235 State Road 17, Culver, Indiana, 46511 (“APT”), Axiom Pharmaceutical Corporation, a Delaware corporation with its principal place of business at c/o Acura Pharmaceuticals, Inc., 616 N. North Court, Suite 120, Palatine, Illinois, 60067 (“Axiom” and, together with Houba, the “Guarantors”), and [Galen Partners III, L.P., a Delaware limited partnership] with its principal place of business at 610 Fifth Avenue, Fifth Floor, New York, New York, 10020, acting in its capacity as agent for the Lenders, as defined below (the “Agent”), for the benefit of the Lenders.

SECURED PROMISSORY NOTE ACURA PHARMACEUTICALS, INC.
Secured Promissory Note • June 23rd, 2005 • Acura Pharmaceuticals, Inc • Pharmaceutical preparations • New York

This Note was issued by the Company pursuant to a certain Loan Agreement dated as of June 22, 2005 among the Company and certain lenders identified therein, including the Payee (together with the Schedules and Exhibits thereto, the “Loan Agreement”). The holders from time to time of the Notes issued under the Loan Agreement (including the Holder) are referred to hereinafter as the “Holders”. The Holder is entitled to the benefits of the Loan Agreement, including, without limitation, the rights upon the occurrence and during the continuance of an Event of Default and the benefits of security interests and guaranties referred to below. Reference is made to the Loan Agreement and the documents entered into pursuant thereto with respect to certain additional rights of the Holder and obligations of the Company and its Subsidiaries not expressly set forth herein. Capitalized terms used herein but not otherwise defined herein shall have the meaning ascribed thereto in the Loan Agreement. All

COMPANY GENERAL SECURITY AGREEMENT
General Security Agreement • June 23rd, 2005 • Acura Pharmaceuticals, Inc • Pharmaceutical preparations • New York

This Company General Security Agreement (the “Agreement”) is dated as of June 22, 2005 by and among Acura Pharmaceuticals, Inc., a New York corporation with its principal place of business at 616 N. North Court, Palatine, Illinois, 60067 (“Debtor”), and Galen Partners III, L.P., a Delaware limited partnership with its principal place of business at 610 Fifth Avenue, Fifth Floor, New York, New York, 10020, acting in its capacity as agent for the Lenders, as defined below (the “Agent”), for the benefit of the Lenders.

Contract
Subordination Agreement • June 23rd, 2005 • Acura Pharmaceuticals, Inc • Pharmaceutical preparations • New York

SUBORDINATION AGREEMENT, dated as of June 22, 2005, by and among Acura Pharmaceuticals, Inc., a New York corporation (the "Company"), the legal and beneficial holders of the Watson Note (the "Watson Holders"), the holders of the 2005 Notes (the "2005 Lenders"), Galen Partners III, L.P., a Delaware limited partnership, as agent for the Watson Holders and the 2005 Lenders (in such capacity, the "Agent") and the Grantors listed on the signature pages hereof.

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