0001144204-06-051169 Sample Contracts

REGISTRATION RIGHTS AGREEMENT
Registration Rights Agreement • December 4th, 2006 • Neoprobe Corp • Surgical & medical instruments & apparatus • Illinois

REGISTRATION RIGHTS AGREEMENT (this "Agreement"), dated as of December 1, 2006, by and between NEOPROBE CORPORATION, a Delaware corporation, (the "Company"), and FUSION CAPITAL FUND II, LLC (together with it permitted assigns, the “Buyer”). Capitalized terms used herein and not otherwise defined herein shall have the respective meanings set forth in the Common Stock Purchase Agreement by and between the parties hereto, dated as of the date hereof (as amended, restated, supplemented or otherwise modified from time to time, the "Purchase Agreement").

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COMMON STOCK PURCHASE AGREEMENT
Common Stock Purchase Agreement • December 4th, 2006 • Neoprobe Corp • Surgical & medical instruments & apparatus • Illinois

COMMON STOCK PURCHASE AGREEMENT (the “Agreement”), dated as of December 1, 2006, by and between NEOPROBE CORPORATION, a Delaware corporation (the “Company”), and FUSION CAPITAL FUND II, LLC, an Illinois limited liability company (the “Buyer”). Capitalized terms used herein and not otherwise defined herein are defined in Section 10 hereof.

AMENDMENT TO SECURITIES PURCHASE AGREEMENT
Securities Purchase Agreement • December 4th, 2006 • Neoprobe Corp • Surgical & medical instruments & apparatus • Delaware

This Amendment to Securities Purchase Agreement (hereinafter referred to as this “Amendment”) dated as of November 30, 2006, is entered into by and among NEOPROBE CORPORATION (the “Company”), a Delaware corporation, BIOMEDICAL VALUE FUND, L.P. (“BVF”), a Delaware limited partnership, BIOMEDICAL OFFSHORE VALUE FUND, LTD. (“BOVF” and together with “BVF,” the “BV Funds”), an exempted company incorporated under the provisions of the Companies Law of the Cayman Islands, and DAVID C. BUPP (“Bupp” and together with the BV Funds, each a “Purchaser” and collectively, the “Purchasers”).

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