0001144204-07-007215 Sample Contracts

CHANGE ORDER FORM
Clinical Research Services Agreement • February 13th, 2007 • Advaxis, Inc. • Pharmaceutical preparations

This Change Order 1 “CO1” is hereby incorporated into the terms and conditions of the Clinical Research Services Agreement dated 04 December 2005 (hereinafter referred to as the “Agreement”) by and between Pharm-Olam International (UK) Limited, (hereinafter referred to as “POI”) and Advaxis, Inc, (hereinafter referred to as “Client”).

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AMENDED AND RESTATED LICENSE AGREEMENT BETWEEN ADVAXIS, INC. (COMPANY) AND THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (PENN) EFFECTIVE DATE: JULY 1, 2002
License Agreement • February 13th, 2007 • Advaxis, Inc. • Pharmaceutical preparations

This Amended and Restated License Agreement (“AGREEMENT”) is between The Trustees of the University of Pennsylvania, a Pennsylvania nonprofit corporation, with offices located at 3160 Chestnut Street, Suite 200, Philadelphia, Pennsylvania 19104-6283 (“PENN”) and Advaxis, Inc., a corporation organized and existing under the laws of Delaware (“COMPANY”), having a place of business at The Technology Centre of New Jersey, Suite 117, 675 U.S. Route 1, North Brunswick, NJ 08902.

SPONSORED RESEARCH AGREEMENT between ADVAXIS, INC. (SPONSOR) and THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (PENN)
Sponsored Research Agreement • February 13th, 2007 • Advaxis, Inc. • Pharmaceutical preparations

This Sponsored Research Agreement ("AGREEMENT") is made by and between The Trustees of the University of Pennsylvania, a Pennsylvania nonprofit corporation ("PENN"), with offices located at Franklin Building, Room P221, 3451 Walnut Street, Philadelphia, PA 19104-6205, and Advaxis, Inc., a corporation organized and existing under the laws of Delaware ("SPONSOR"), having a place of business at 675 Route 1, Ste 113B, N. Brunswick, NJ 08902.

CLINICAL RESEARCH SERVICES AGREEMENT BETWEEN ADVAXIS, INC AND APOTHECARIES LIMITED.
Clinical Research Services Agreement • February 13th, 2007 • Advaxis, Inc. • Pharmaceutical preparations • Delhi

This Clinical Research Services Agreement (this Agreement) is made and entered into effective as of 28 Oct. 2006, by and between Advaxis, Inc. (hereafter “THE COMPANY”), a Delaware Company with its principal office at 675 Route 1, North Brunswick, New Jersey 08902, and APOTHECARIES LIMITED. (hereafter “APOTHECARIES ”), a corporation organized under the laws of India, with its principal office at 579, Devli, East Sainik Farms, New Delhi 110062, India.

THIRD LEASE AMENDMENT AGREEMENT
Lease Amendment • February 13th, 2007 • Advaxis, Inc. • Pharmaceutical preparations

THIS THIRD LEASE AMENDMENT AGREEMENT, made as of the 1ST day of October, 2006 (the “LEASE Amendment”) is by and between ADVAXIS, INC.(“TENANT”), and the NEW JERSEY ECONOMIC DEVELOPMENT AUTHORITY (“LANDLORD”).

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