0001144204-07-012076 Sample Contracts

REGISTRATION RIGHTS AGREEMENT
Registration Rights Agreement • March 9th, 2007 • Gentium S.p.A. • Pharmaceutical preparations

Each selling security holder and any of their pledgees, assignees and successors-in-interest may, from time to time, sell any or all of their ADSs on the Nasdaq Global Market System or any other stock exchange, market or trading facility on which the ADSs are traded or in private transactions. These sales may be at fixed or negotiated prices. A selling security holder may use any one or more of the following methods when selling ADSs:

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AMENDMENT NO. 3 TO CLINICAL TRIAL AGREEMENT
Clinical Trial Agreement • March 9th, 2007 • Gentium S.p.A. • Pharmaceutical preparations

This AMENDMENT NO. 3 TO CLINICAL TRIAL AGREEMENT (this “Amendment 3”) is made and entered into as of April 1, 2006 by and between Gentium S.p.A. (successor in interest to Crinos Industria Farmacobiologica S.p.A.), an Italian joint stock corporation having an office at Piazza II Settembre 2, 22079 Villa Guardia (Como), Italy (the “Company”) and Dana-Farber/Partners Cancer Care, Inc., a non-profit corporation having an office at 44 Binney Street, Boston, Massachusetts, 02115, USA (“DFPCC”).

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