0001144204-10-001379 Sample Contracts

Re: Amendments to License and Supply and Cost Sharing Agreements
License and Supply Agreement • January 11th, 2010 • Gentium S.p.A. • Pharmaceutical preparations

Reference is made to the License and Supply Agreement dated as of December 7, 2001, as amended on June 14, 2005 (“First Amendment”), between Gentium S.p.A. (“Gentium”) and Sigma-Tau Pharmaceuticals, Inc. (“Sigma-Tau”) (collectively the “License Agreement”), and the Cost Sharing Agreement dated as of October 12, 2007 between Gentium and Sigma-Tau (the “Cost Sharing Agreement” and together with the License Agreement, the “Agreements”). All capitalized terms not defined herein shall have the meanings ascribed to such terms in the Agreements.

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