0001144204-11-006288 Sample Contracts

AMENDMENT TO STOCK PURCHASE AGREEMENT
Stock Purchase Agreement • February 7th, 2011 • Ziopharm Oncology Inc • Services-specialty outpatient facilities, nec • New York

This Amendment, dated as of February 1, 2011 (this “Amendment”), to the Stock Purchase Agreement, dated as of January 6, 2011 (the “Purchase Agreement”), by and between ZIOPHARM Oncology, Inc., a Delaware corporation (the “Company”), and Intrexon Corporation, a Virginia corporation (“Intrexon”). Capitalized terms used in this Amendment and not otherwise defined shall have the respective meanings ascribed to such terms in the Purchase Agreement.

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