0001144204-12-043694 Sample Contracts

AMENDMENT NO. 1 TO EXCHANGE TRANSACTION AGREEMENT
Exchange Transaction Agreement • August 8th, 2012 • Tg Therapeutics, Inc. • Pharmaceutical preparations

This Amendment No. 1 (this “Amendment”) to that certain Exchange Transaction Agreement (the “Agreement”), dated as of December 29, 2011, by and among Opus Point Partners, LLC, a Delaware corporation (“Opus”), TG Biologics, Inc. (f/k/a TG Therapeutics, Inc.), a Delaware corporation (“TG Biologics”) and TG Therapeutics, Inc. (f/k/a Manhattan Pharmaceuticals, Inc.), a Delaware corporation (“TG Therapeutics”), is entered into by and among the aforementioned parties (Opus, TG Biologics and TG Therapeutics, collectively, the “Parties”), this 2nd day of August 2012. TG Therapeutics agrees to be bound by the terms and conditions of the Agreement, as amended herein. All capitalized terms not herein defined shall have the meaning ascribed to them in the Agreement and that certain Confidential Offering Memorandum, dated December 1, 2011, as amended or supplemented from time to time, including all attachments, schedules and exhibits thereto.

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