0001144204-12-043904 Sample Contracts

STOCK ISSUANCE AGREEMENT
Stock Issuance Agreement • August 9th, 2012 • Synthetic Biologics, Inc. • Pharmaceutical preparations • New York
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FIRST AMENDMENT TO REGISTRATION RIGHTS AGREEMENT
Registration Rights Agreement • August 9th, 2012 • Synthetic Biologics, Inc. • Pharmaceutical preparations

This First Amendment to Registration Rights Agreement (this “Amendment”) is made and entered into as of August 6, 2012, by and among Synthetic Biologics, Inc., a Nevada corporation, previously known as Adeona Pharmaceuticals, Inc. (the “Company”), and Intrexon Corporation, a Virginia corporation (“Intrexon”) to amend the Registration Rights Agreement dated December 5, 2011, by and among the Company and Intrexon (the “Registration Rights Agreement”).

Exclusive Channel Collaboration Agreement
Collaboration Agreement • August 9th, 2012 • Synthetic Biologics, Inc. • Pharmaceutical preparations • New York

This Exclusive Channel Collaboration Agreement (the “Agreement”) is made and entered into effective as of August 6, 2012 (the “Effective Date”) by and between Intrexon Corporation, a Virginia corporation with offices at 20358 Seneca Meadows Parkway, Germantown, MD 20876 (“Intrexon”), and Synthetic Biologics, Inc., a Nevada corporation having its principal place of business at 617 Detroit Street, Suite 100, Ann Arbor, MI 48104 (“Synthetic”). Intrexon and Synthetic may be referred to herein individually as a “Party”, and collectively as the “Parties.”

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