0001144204-13-068826 Sample Contracts

Lease agreement for real property not for use as dwelling (the “Agreement”) between
Lease Agreement • December 24th, 2013 • Gentium S.p.A. • Pharmaceutical preparations

FinSirton S.p.A. with a company capital of 479,928.00 euro and registered office in Villa Guardia, Piazza XX Settembre n. 2, companies’ register, VAT number and tax identification number 02827580131; represented here by its accountant Angelo Aredi Butti, born in Como on 5/10/1967, domiciled for this office at the company, who declares that is acting here as Sole Director, being vested with all necessary powers (and hereinafter referred to as the “Lessor”);

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CONSULTANCY AGREEMENT
Consultancy Agreement • December 24th, 2013 • Gentium S.p.A. • Pharmaceutical preparations
Lugano, August 31, 2010 RE: Employment agreement with Gentium S.p.A., Lugano branch
Gentium S.p.A. • December 24th, 2013 • Pharmaceutical preparations

Following our agreements, Gentium S.p.A. (hereinafter, the “Company”) and Mr. Khalid Islam hereby intend to terminate by mutual consent, with effect from August 31, 2010, the employment agreement entered into by the same parties on June 1, 2010, and, at the same time, the Company intends to hire Mr. Islam pursuant to the terms and conditions set forth herein.

TRANSITION, AMENDMENT AND RELEASE AGREEMENT
And Release Agreement • December 24th, 2013 • Gentium S.p.A. • Pharmaceutical preparations

WHEREAS, the Employee is currently employed by the Company pursuant to an employment agreement concluded between the Employee and Gentium S.p.A. on August 31, 2010, as amended on July 31, 2011 and November 11, 2013, which was transferred to the Company on November 1, 2012 (the employment agreement as amended referred to as “Employment Agreement”);

RETENTION AND AMENDMENT AGREEMENT
Retention and Amendment Agreement • December 24th, 2013 • Gentium S.p.A. • Pharmaceutical preparations

THIS RETENTION AND AMENDMENT AGREEMENT (together with the Confidentiality and IP Rights Agreement attached hereto as Exhibit 1, the “Confidentiality Agreement” and, together with this Retention and Amendment Agreement, the "Agreement") is hereby made effective this December 19, 2013 (the "Effective Date") between the Gentium S.p.A., with registered office in Piazza XX Settembre, 2 – 22079 Villa Guardia (CO) Italy, Tax code 02098100130 (hereinafter referred to as the “Company”) in the person of Khalid Islam,CEO of the Company and Salvatore Calabrese born in Locri (RC), on January 4, 1970, resident in Milano, Via Domenico Cirillo, 10, Tax code: CLBSVT70A04D976G (hereinafter referred to as the “Employee”).

RETENTION AND AMENDMENT AGREEMENT
Retention and Amendment Agreement • December 24th, 2013 • Gentium S.p.A. • Pharmaceutical preparations

WHEREAS, the Employee is currently employed by the Company pursuant to an employment agreement dated May 22, 2013, as amended on December 2, 2013, and October 28, 2013 (the employment agreement as amended referred to as “Employment Agreement”);

RETENTION AND AMENDMENT AGREEMENT
Retention and Amendment Agreement • December 24th, 2013 • Gentium S.p.A. • Pharmaceutical preparations

WHEREAS, the Employee is currently employed by the Company pursuant to an employment agreement concluded between the Employee and Gentium S.p.A on March 1, 2011, as amended by an agreement on July 20, 2011, which was transferred to the Company by agreement dated September 30, 2011 as amended on November 11, 2013 (the employment agreement as amended referred to as “Employment Agreement”);

September 7, 2007
Gentium S.p.A. • December 24th, 2013 • Pharmaceutical preparations

In accordance with our previous understandings, we wish to confirm that it is the intention of Gentium S.p.A. (hereinafter the "Company") to enter into this indefinite term employment agreement with upon the terms and conditions hereinafter specified.

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