0001144204-17-065910 Sample Contracts

FIFTH AMENDMENT AND WAIVER
And Waiver • December 29th, 2017 • Xtant Medical Holdings, Inc. • Biological products, (no disgnostic substances) • New York

This FIFTH AMENDMENT AND WAIVER (this “Amendment and Waiver”) is made and entered into as of December 28, 2017 by XTANT MEDICAL HOLDINGS, INC., a Delaware corporation (the “Company”), ROS acquisition offshore lp, a Cayman Islands Exempted Limited Partnership (“ROS”) and ORBIMED ROYALTY OPPORTUNITIES II, LP, a Delaware limited partnership (“Royalty Opportunities” and, together with ROS, collectively, the “Holders”).

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TWENTy-First AMENDMENT TO AMENDED AND RESTATED CREDIT AGREEMENT
Credit Agreement • December 29th, 2017 • Xtant Medical Holdings, Inc. • Biological products, (no disgnostic substances) • New York

This TWENTy-First AMENDMENT TO AMENDED AND RESTATED CREDIT AGREEMENT (this “Amendment”) is made and entered into as of December 28, 2017 (the “Amendment Closing Date”) by and among Bacterin International, Inc., a Nevada corporation (the “Borrower”), ROS acquisition offshore lp, a Cayman Islands Exempted Limited Partnership (“ROS”), ORBIMED ROYALTY OPPORTUNITIES II, LP, a Delaware limited partnership (“Royalty Opportunities”), and, in their capacity as Guarantors under the Credit Agreement (as defined below), XTANT MEDICAL HOLDINGS, INC., a Delaware corporation (“Holdings”), X-SPINE SYSTEMS, INC., an Ohio corporation (“X-Spine” or the “Additional Delayed Draw Borrower” and, together with the Borrower, the “Borrowers”) and XTANT MEDICAL, INC., a Delaware corporation (“Xtant” and, along with Holdings and X-Spine, collectively, the “Guarantors”).

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