0001144204-18-003172 Sample Contracts

SIXTH AMENDMENT
Sixth Amendment • January 23rd, 2018 • Xtant Medical Holdings, Inc. • Biological products, (no disgnostic substances) • New York

This SIXTH AMENDMENT (this “Amendment”) is effective as of January 17, 2018 by XTANT MEDICAL HOLDINGS, INC., a Delaware corporation (the “Company”), ROS acquisition offshore lp, a Cayman Islands Exempted Limited Partnership (“ROS”) and ORBIMED ROYALTY OPPORTUNITIES II, LP, a Delaware limited partnership (“Royalty Opportunities” and, together with ROS, collectively, the “Holders”).

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