0001144204-19-039522 Sample Contracts

ROYALTY AGREEMENT
Royalty Agreement • August 13th, 2019 • Aevi Genomic Medicine, Inc. • Biological products, (no disgnostic substances) • Pennsylvania

This Royalty Agreement dated as of July 19, 2019 (as amended, supplemented or otherwise modified from time to time, this “Royalty Agreement”) is made by Michael F. Cola, Joseph J. Grano, Jr., Kathleen Jane Grano, Joseph C. Grano, The Grano Children’s Trust, Joseph C. Grano, trustee and LeoGroup Private Investment Access, LLC on behalf of Garry A. Neil (each individually, an “Investor” and collectively, the “Investors”) and Aevi Genomic Medicine, Inc. (“Aevi”). Investors and Aevi are sometimes referred to herein individually as a “Party” and collectively as the “Parties.”

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AMENDMENT NO. 4 TO SPONSORED RESEARCH AGREEMENT
Sponsored Research Agreement • August 13th, 2019 • Aevi Genomic Medicine, Inc. • Biological products, (no disgnostic substances)

This Amendment No. 4 to Sponsored research Agreement (this “Amendment”) is entered into as of August 12, 2019 and is effective as of June 28, 2019 (the “Amendment Date”), by and between Medgenics Medical Israel Ltd. (“Sponsor”), a company organized under the laws of the State of Israel and wholly owned subsidiary of Aevi Genomic Medicine, Inc., a Delaware corporation (“Aevi”), and The Children’s Hospital of Philadelphia, a non-profit entity organized and existing under the laws of Pennsylvania (“CHOP”). CHOP and Sponsor are sometimes referred to in this Amendment individually as a “Party” or, collectively, as the “Parties.”

AMENDMENT NO. 3 TO LICENSE AGREEMENT
License Agreement • August 13th, 2019 • Aevi Genomic Medicine, Inc. • Biological products, (no disgnostic substances)

This Amendment No. 3 to License Agreement (this “Amendment”) is entered into as of August 12, 2019 and is effective as of June 28, 2019 (the “Amendment Date”), by and between Medgenics Medical Israel Ltd. (“Licensee”), a company organized under the laws of the State of Israel and wholly owned subsidiary of Aevi Genomic Medicine, Inc., a Delaware corporation (“Aevi”), and The Children’s Hospital of Philadelphia, a non-profit entity organized and existing under the laws of Pennsylvania (“CHOP”). CHOP and Licensee are sometimes referred to in this Amendment individually as a “Party” and collectively as the “Parties.”

EXCLUSIVE license AGREEMENT by and between OSI pharmaCEUTICALS, llc and Aevi Genomic Medicine, Inc. July 15, 2019 EXCLUSIVE LICENSE AGREEMENT
Exclusive License Agreement • August 13th, 2019 • Aevi Genomic Medicine, Inc. • Biological products, (no disgnostic substances) • New York
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