Exhibit 4.1 SERVICE AGREEMENT DATED 21st MARCH 2003 (1) BRITISH BIOTECH PLC (2) DR P FELLNERService Agreement • October 31st, 2003 • Vernalis PLC • Pharmaceutical preparations
and-Agreement • October 31st, 2003 • Vernalis PLC • Pharmaceutical preparations • England
Country Application Application Patent No Grant Date Expiry Status No Date Date P=Pending/ G=Granted Czech Republic PV2861-93 17/06/1992 282083 27/08/1997 17/06/2012 G Czech Div 1 1505-96 24/05/1996 282061 27/08/1997 17/06/2012 G Europe A* 92204003.5 18/12/1992 603432 21/10/1998 18/12/2012 G Europe ** 92912379.2 17/06/1992 591280 09/09/1998 17/06/2012 G Finland 935842 17/06/1992 P Hungary P9303731 17/06/1992 P Ireland 922062 01/07/1992 P Kazakhstan 933243.1 17/06/1992 P Norway 93.4800 17/06/1992 304774 15/02/1999 17/06/2012 G Poland P301883 17/06/1992 169392 14/12/1995 17/06/2012 G Poland P307118 10/02/1995 169410 14/12/1995 17/06/2012 G Poland P311304 22/11/1995 171034 03/09/1996 17/06/2012 G Portugal 100620 24/06/1992 P Russia 93058534.00 17/06/1992 P Slovenia P9200125 26/06/1992 9200125 15/03/1993 26/06/2012 G Slovakia PV1319-93 17/06/1992 P Slovakia PV1054-98 05/08/1998 Ukraine 93002251 17/06/1992 P
