0001157523-11-004734 Sample Contracts

SECOND AMENDMENT TO JOINT DEVELOPMENT AND LICENSE AGREEMENT
Joint Development and License Agreement • August 4th, 2011 • Dyax Corp • Services-commercial physical & biological research

This SECOND AMENDMENT (the "Second Amendment"), dated as of May 27, 2011 (the "Second Amendment Date"), is entered into by and between Dyax Corp., with principal offices at 300 Technology Square, Cambridge, Massachusetts 02139, U.S.A. ("Dyax"), and Defiante Farmacêutica S.A., with registered offices at Rua da Alfândega, n. 78, 3° andar, 9000-059, Funchal, Madeira, Portugal ("Defiante"). This Second Amendment further amends that certain Joint Development and License Agreement (the "Original Agreement"), dated effective as of June 18, 2010 (the "Effective Date") as amended by the First Amendment to Joint Development and License Agreement (the "First Amendment”), dated December 21, 2011 (the "First Amendment Date"). The Original Agreement as amended by the First Amendment, is referred to herein as the "Amended Agreement." All capitalized terms not otherwise defined in this Second Amendment shall be as defined in the Amended Agreement.

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