0001171843-16-009701 Sample Contracts

SECURITIES PURCHASE AGREEMENT
Securities Purchase Agreement • May 5th, 2016 • Sucampo Pharmaceuticals, Inc. • Pharmaceutical preparations • New York

This Securities Purchase Agreement (this “Agreement”) is dated as of January 9, 2016 by and between Cancer Prevention Pharmaceuticals, Inc., a Delaware corporation (the “Company”), and Sucampo AG, a Swiss corporation, and a wholly owned subsidiary of Sucampo Pharmaceuticals, Inc., a Delaware corporation (together, the “Purchaser”).

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SEPARATION AGREEMENT AND RELEASES
Separation Agreement and Releases • May 5th, 2016 • Sucampo Pharmaceuticals, Inc. • Pharmaceutical preparations

This Separation Agreement and Releases (“Separation Agreement”) is made and entered into as of the 29th day of February, 2016, by and between Stanley Miele (hereinafter “Executive”) and Sucampo Pharmaceuticals, Inc. (“SPI”), a corporation organized under the laws of the State of Delaware, and its affiliates (hereinafter collectively referred to as the “Company”).

EMPLOYMENT AGREEMENT
Employment Agreement • May 5th, 2016 • Sucampo Pharmaceuticals, Inc. • Pharmaceutical preparations • Delaware

2015, is hereby entered into in the State of Maryland by and between SUCAMPO PHARMACEUTICALS, INC., a Delaware limited liability company (the "Company"), and Andrew Smith ("Executive").

OPTION AND COLLABORATION AGREEMENT
Option and Collaboration Agreement • May 5th, 2016 • Sucampo Pharmaceuticals, Inc. • Pharmaceutical preparations • New York

This Option and Collaboration Agreement (“Agreement”) dated 9th day of January, 2016 (“Effective Date”) by and between Cancer Prevention Pharmaceuticals, Inc., a corporation organized and existing under the laws of the State of Delaware, having a place of business at 1760 East River Road, Suite 250, Tucson, Arizona 85718 (“CPP”), and Sucampo AG, a corporation organized and existing under the laws of Switzerland, having a place of business at Baarerstrasse 22, 6300 Zug, Switzerland (“Sucampo”). CPP and Sucampo are referred to in this Agreement individually as a “Party” and collectively as the “Parties.”

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