AMENDMENT AGREEMENTSecurities Purchase Agreement • May 14th, 2021 • Palisade Bio, Inc. • Biological products, (no disgnostic substances) • New York
Contract Type FiledMay 14th, 2021 Company Industry JurisdictionTHIS AMENDMENT AGREEMENT (this "Amendment") is entered into and made effective as of May 3, 2021, by and among Palisade Bio, Inc., a Delaware corporation formerly known as Seneca Biopharma, Inc. (the "Company"), Leading Biosciences, Inc., a Delaware corporation ("PrivateCo") and the investor listed on the signature page attached hereto (the "Buyer").