0001171843-21-003532 Sample Contracts

AMENDMENT AGREEMENT
Securities Purchase Agreement • May 14th, 2021 • Palisade Bio, Inc. • Biological products, (no disgnostic substances) • New York

THIS AMENDMENT AGREEMENT (this "Amendment") is entered into and made effective as of May 3, 2021, by and among Palisade Bio, Inc., a Delaware corporation formerly known as Seneca Biopharma, Inc. (the "Company"), Leading Biosciences, Inc., a Delaware corporation ("PrivateCo") and the investor listed on the signature page attached hereto (the "Buyer").

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