0001181431-06-013173 Sample Contracts

SECOND AMENDMENT TO THE RESEARCH AGREEMENT
The Research Agreement • February 21st, 2006 • Trimeris Inc • Biological products, (no disgnostic substances)

This SECOND AMENDMENT TO THE RESEARCH AGREEMENT ("Second Amendment") is executed to be effective this 31st day of December 2005 ("Second Amendment Effective Date"), by and between Trimeris, Inc. ("Trimeris"), and F. Hoffmann-La Roche Ltd and Hoffmann-La Roche Inc. (collectively, "Roche") (Roche and Trimeris together referred to as the "Parties").

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