0001193125-03-032978 Sample Contracts

COUNTY OF DURHAM SECOND AMENDMENT TO LEASE
Lease • August 11th, 2003 • Inspire Pharmaceuticals Inc • Pharmaceutical preparations

THIS SECOND AMENDMENT TO LEASE (the “Second Amendment”) is made and entered into as of the 6th day of June, 2003, by and between ROYAL CENTER IC, LLC, a Delaware limited liability company (“Landlord”) [successor-in-interest to Royal Center Two IC, LLC, a Delaware limited liability company (“RC Two”) and Petula Associates, Ltd., an Iowa corporation (“Petula”)] and INSPIRE PHARMACEUTICALS, INC., a Delaware corporation (“Tenant”).

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FORM OF INSPIRE PHARMACEUTICALS, INC. DIRECTOR NON-STATUTORY STOCK OPTION AGREEMENT
Director Non-Statutory Stock Option Agreement • August 11th, 2003 • Inspire Pharmaceuticals Inc • Pharmaceutical preparations

Inspire Pharmaceuticals, Inc. (the “Company”), a Delaware corporation, as an incentive and inducement to (the “Optionee”), who is presently a member of the Board of Directors of the Company (the “Board”) [and a member of the audit committee of the Board (the “Audit Committee”)], to devote his or her best efforts to the affairs of the Company, which incentive and inducement the Board has determined to be sufficient consideration for the grant of this option, hereby grants to the Optionee the right and option (the “Option”) to purchase shares of the Company’s common stock, $0.001 par value per share (the “Common Stock”) under the following terms:

FORM OF INSPIRE PHARMACEUTICALS, INC. EMPLOYEE STOCK OPTION AGREEMENT
Employee Stock Option Agreement • August 11th, 2003 • Inspire Pharmaceuticals Inc • Pharmaceutical preparations

Inspire Pharmaceuticals, Inc. (the “Company”), a Delaware corporation, as an incentive and inducement to the Optionee, who is presently an employee of the Company, to devote his or her best efforts to the affairs of the Company, which incentive and inducement the Board of Directors of the Company or a committee of the Board of Directors (either, the “Board”) has determined to be sufficient consideration for the grant of this option, hereby grants to the Optionee the right and option (the “Option”) to purchase shares of the Company’s Common Stock, $0.001 par value per share (the “Stock”), under the following terms:

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