0001193125-03-078676 Sample Contracts

4,500,000 Shares ISTA PHARMACEUTICALS, INC. COMMON STOCK UNDERWRITING AGREEMENT Dated November , 2003
Underwriting Agreement • November 12th, 2003 • Ista Pharmaceuticals Inc • In vitro & in vivo diagnostic substances • New York

Introduction. ISTA PHARMACEUTICALS, INC., a Delaware corporation (the “Company”), proposes to issue and sell to the several underwriters named in Schedule A hereto (the “Underwriters”), and certain stockholders of the Company (the “Selling Stockholders”) named in Schedule B hereto severally propose to sell to the several Underwriters, an aggregate of 4,500,000 shares of the Common Stock, par value $0.001 per share, of the Company (the “Firm Shares”), of which 4,000,000 shares are to be issued and sold by the Company and 500,000 shares are to be sold by the Selling Stockholders, with each Selling Stockholder selling the number of shares set forth opposite such Selling Stockholder’s name in Schedule B hereto.

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