0001193125-03-098767 Sample Contracts

May 22, 2001 HELSINN HEALTHCARE SA
Mgi Pharma Inc • December 23rd, 2003 • Pharmaceutical preparations
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AMENDMENT No. 1 TO THE SUPPLY AND PURCHASE AGREEMENT
Supply and Purchase Agreement • December 23rd, 2003 • Mgi Pharma Inc • Pharmaceutical preparations

This Amendment No. 1 (“Amendment”) to the License Agreement is made and effective as of this 14th day of November, 2003 between HELSINN BIREX PHARMACEUTICALS Ltd., a corporation organized and existing under the laws of Ireland and having its registered office at Damastown, Mulhuddart, Dublin 15, Republic of Ireland (hereinafter called “HBP”), of the one part, and MGI PHARMA, INC., a corporation organized and existing under the law of the state of Minnesota, United States of America and having its registered office at 5775 West Old Shakopee Road, Suite 100, Bloomington, MN 55437-3174, USA (hereinafter called “MGI”), of the other part.

AMENDMENT No. 2 TO THE LICENSE AGREEMENT
The License Agreement • December 23rd, 2003 • Mgi Pharma Inc • Pharmaceutical preparations

This Amendment No. 2 (“Amendment”) to the License Agreement is made and effective as of this 14th day of November, 2003 between HELSINN HEALTHCARE SA, a corporation organized and existing under the laws of Switzerland and having its registered office at Via Pian Scairolo 9, 6912 Pazzallo, Switzerland (hereinafter called “HHC”), of the one part, and MGI PHARMA, INC., a corporation organized and existing under the law of the state of Minnesota, United States of America and having its registered office at 5775 West Old Shakopee Road, Suite 100, Bloomington, MN 55437-3174, USA (hereinafter called “MGI”), of the other part.

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