0001193125-04-040087 Sample Contracts

FIRST AMENDMENT TO THE RESEARCH AGREEMENT
The Research Agreement • March 12th, 2004 • Trimeris Inc • Biological products, (no disgnostic substances)

This AMENDMENT TO THE RESEARCH AGREEMENT (“Amendment”) is executed to be effective this 13th day of November 2003, by and between Trimeris, Inc. (“Trimeris”), and F. Hoffmann-La Roche Ltd. and Hoffmann-La Roche Inc. (collectively, “Roche”).

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SUBLEASE
Trimeris Inc • March 12th, 2004 • Biological products, (no disgnostic substances)

THIS AGREEMENT OF SUBLEASE (“Sublease”), dated as of the 31st day of October, 2003, by and between GILEAD SCIENCES, INC., a Delaware corporation (“Sublandlord”), and TRIMERIS, INC., a Delaware corporation (“Subtenant”).

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AMENDMENT TO THE DEVELOPMENT AND LICENSE AGREEMENT
Development and License Agreement • March 12th, 2004 • Trimeris Inc • Biological products, (no disgnostic substances)

This AMENDMENT TO THE DEVELOPMENT AND LICENSE AGREEMENT (“Amendment”) is executed to be effective this 5th day of January 2004, by and between Trimeris, Inc. (“Trimeris”), and F. Hoffmann-La Roche Ltd. and Hoffmann-La Roche Inc. (collectively, “Roche”).

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