0001193125-04-044311 Sample Contracts

Re: Addendum to the Employment Letter dated February 11, 2003 Dear Marvin:
Sirna Therapeutics Inc • March 18th, 2004 • Pharmaceutical preparations

This letter shall serve as an addendum to the terms of employment letter with Sirna Therapeutics, Inc. (the “Company”) dated February 11, 2003 (the “Employment Agreement”). You hereby acknowledge your acceptance of this addendum (the Addendum”) on such terms as detailed below.

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