0001193125-04-047521 Sample Contracts

AGREEMENT AND PLAN OF MERGER AMONG PARADIGM GENETICS, INC., TISSUEINFORMATICS.INC AND THE INDEMNIFICATION REPRESENTATIVE Dated as of January 29, 2004
Agreement and Plan of Merger • March 24th, 2004 • Paradigm Genetics Inc • Services-commercial physical & biological research • Delaware

AGREEMENT AND PLAN OF MERGER (this “Agreement”), made and entered into as of January 29, 2004 by and among Paradigm Genetics, Inc., a Delaware corporation (“Parent”), TissueInformatics.Inc, a Delaware corporation (the “Company”) and TVM V Life Science Ventures GmbH & Co., as the indemnification representative of the Company Stockholders (the “Indemnification Representative”). Parent, the Company and the Indemnification Representative are sometimes referred to herein each individually as a “Party” and, collectively, as the “Parties.”

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FIRST AMENDMENT TO THE AGREEMENT AND PLAN OF MERGER
The Agreement and Plan of Merger • March 24th, 2004 • Paradigm Genetics Inc • Services-commercial physical & biological research

This First Amendment (this “Amendment”) to the Agreement and Plan of Merger is entered into by and between Paradigm Genetics, Inc. (“Parent”) and TissueInformatics.Inc (the “Company”) effective as of March 10, 2004.

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