0001193125-04-053761 Sample Contracts

AMENDMENT TO LICENSE AGREEMENT
License Agreement • March 30th, 2004 • Senetek PLC /Eng/ • Biological products, (no disgnostic substances)

This Amendment (the “Amendment”) is made and entered into as of December 1, 2003 to the License Agreement (the “Agreement”) made and entered into as of August 1,2003, by and between Senetek PLC, an English corporation with its corporate headquarters located at 620 Airpark Road, Napa, California 94558 (“Senetek”), and Valeant Pharmaceuticals International (formerly known as ICN Pharmaceuticals, Inc.), a Delaware corporation with its corporate headquarters located at 3300 Hyland Avenue, Costa Mesa, California 92626 ( “Licensee”). Capitalized terms used herein and not otherwise defined are used with the meanings ascribed to them in the Agreement.

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