0001193125-04-135946 Sample Contracts

Amendment to 6 August 1982 Insulin Agreement
Insulin Agreement • August 9th, 2004 • Zymogenetics Inc • Biological products, (no disgnostic substances)

This Amendment of May 18, 2004 (“Amendment Agreement”) to the Insulin Agreement and the 1987 Agreement (as defined below) is entered into between Novo Nordisk A/S, a Danish corporation having a principal place of business at Novo Alle, DK-2880, Bagsvaerd, Denmark (“Novo Nordisk”) and ZymoGenetics Inc., a Washington Corporation having a principal place of business at 1201 Eastlake Avenue East, Seattle, Washington 98102 (“ZGI”).

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AMENDMENT NO. 2 TO LEASE LAKE UNION STEAM PLANT BUILDING
Lease • August 9th, 2004 • Zymogenetics Inc • Biological products, (no disgnostic substances)

This AMENDMENT NO. 2 TO LEASE (this “Amendment”) is entered into as of the below date between ARE-1201/1208 EASTLAKE AVENUE, LLC, a Delaware limited liability company (“Landlord”) and ZYMOGENETICS, INC., a Washington corporation (“Tenant”).

Addendum to 6 August 1982 Insulin Agreement
Insulin Agreement • August 9th, 2004 • Zymogenetics Inc • Biological products, (no disgnostic substances)

This Addendum of May 18, 2004 (“Effective Date”) to the Insulin Agreement (as defined below) is entered into between Novo Nordisk A/S, a Danish corporation having a principal place of business at Novo Alle, DK-2880, Bagsvaerd, Denmark (“Novo Nordisk”) and ZymoGenetics Inc., a Washington Corporation having a principal place of business at 1201 Eastlake Avenue East, Seattle, Washington 98102 (“ZGI”).

AMENDMENT NO. 2 TO LEASE EARL DAVIE BUILDING
Lease • August 9th, 2004 • Zymogenetics Inc • Biological products, (no disgnostic substances)

This AMENDMENT NO. 2 TO LEASE (this “Amendment”) is entered into as of the below date between ARE-1208 EASTLAKE AVENUE, LLC, a Delaware limited liability company (“Landlord”) and ZYMOGENETICS, INC., a Washington corporation (“Tenant”).

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