0001193125-04-147670 Sample Contracts

AMENDMENT No. 1 TO THE SUPPLY AND PURCHASE AGREEMENT
Supply and Purchase Agreement • August 27th, 2004 • Mgi Pharma Inc • Pharmaceutical preparations

This Amendment No. 1 (“Amendment”) to the License Agreement is made and effective as of this 14 day of November, 2003 between HELSINN BIREX PHARMACEUTICALS Ltd., a corporation organized and existing under the laws of Ireland and having its registered office at Damastown, Mulhuddart, Dublin 15, Republic of Ireland (hereinafter called “HBP”), of the one part, and MGI PHARMA, INC., a corporation organized and existing under the law of the state of Minnesota, United States of America and having its registered office at 5775 West Old Shakopee Road, Suite 100, Bloomington, MN 55437-3174, USA (hereinafter called “MGI”), of the other part.

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HELSINN HEALTHCARE SA
Mgi Pharma Inc • August 27th, 2004 • Pharmaceutical preparations
AMENDMENT No. 2 TO THE LICENSE AGREEMENT
The License Agreement • August 27th, 2004 • Mgi Pharma Inc • Pharmaceutical preparations

This Amendment No. 2 (“Amendment”) to the License Agreement is made and effective as of this 14 day of November 2003 between HELSINN HEALTHCARE SA, a corporation organized and existing under the laws of Switzerland and having its registered office at Via Pian Scairolo 9, 6912 Pazzallo, Switzerland (hereinafter called “HHC”), of the one part, and MGI PHARMA, INC., a corporation organized and existing under the law of the state of Minnesota, United States of America and having its registered office at 5775 West Old Shakopee Road, Suite 100, Bloomington, MN 55437-3174, USA (hereinafter called “MGI”), of the other part.

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