0001193125-04-195233 Sample Contracts

SECOND MODIFICATION TO CREDIT AGREEMENT AND PROMISSORY NOTE
Credit Agreement and Promissory Note • November 12th, 2004 • Biosphere Medical Inc • Pharmaceutical preparations • Massachusetts

This SECOND MODIFICATION TO CREDIT AGREEMENT AND PROMISSORY NOTE (this “Agreement”) is made as of the 30th day of June, 2004, by and between BIOSPHERE MEDICAL, INC., a Delaware corporation (the “Borrower”), and BROWN BROTHERS HARRIMAN & CO., a New York general partnership with an office at 40 Water Street, Boston, Massachusetts 02109 (the “Lender”), in the following circumstances:

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