0001193125-05-037513 Sample Contracts

FOURTH SUPPLEMENTAL INDENTURE
Fourth Supplemental Indenture • February 25th, 2005 • Pacificare Health Systems Inc /De/ • Hospital & medical service plans • New York

This Fourth Supplemental Indenture (this “Fourth Supplemental Indenture”) dated as of December 13, 2004, by and between PacifiCare Health Systems, Inc., a Delaware corporation (the “Company”); PacifiCare Health Plan Administrators, Inc., an Indiana corporation, PacifiCare eHoldings, Inc., a California corporation, MEDeMORPHUS Healthcare Solutions, Inc. (formerly known as RxConnect, Inc.), a California corporation, SeniorCo, Inc., a Delaware corporation, Rx Solutions, Inc., a California corporation, PacifiCare Behavioral Health, Inc., a Delaware corporation, Secure Horizons USA, Inc., a California corporation, PacifiCare of Arizona, Inc., an Arizona corporation, PacifiCare Oklahoma, Inc., an Oklahoma corporation, and PacifiCare Southwest Operations, Inc., a Delaware corporation (collectively, the “Existing Subsidiary Guarantors”); and American Medical Security Group, Inc, a Wisconsin corporation (the “Additional Subsidiary Guarantor”); and U.S. Bank National Association, a national bank

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