0001193125-05-052487 Sample Contracts

5.5% SENIOR CONVERTIBLE NOTE DUE 2008-2010 OF INSMED INCORPORATED
Convertible Note • March 16th, 2005 • Insmed Inc • Pharmaceutical preparations • New York
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INSMED INCORPORATED Common Stock Purchase Warrant
Common Stock Purchase Warrant • March 16th, 2005 • Insmed Inc • Pharmaceutical preparations • New York

INSMED INCORPORATED, a Virginia corporation, hereby certifies that, for value received, , or registered assigns (the “Holder”), is entitled, subject to the terms set forth below, to purchase from the Company at any time or from time to time before 5:00 p.m., New York City time, on the Expiration Date (such capitalized term and all other capitalized terms used herein having the respective meanings provided herein), fully paid and nonassessable shares of Common Stock at a purchase price per share equal to the Purchase Price. The number of such shares of Common Stock and the Purchase Price are subject to adjustment as provided in this Warrant.

REGISTRATION RIGHTS AGREEMENT
Registration Rights Agreement • March 16th, 2005 • Insmed Inc • Pharmaceutical preparations • New York

THIS REGISTRATION RIGHTS AGREEMENT, dated as of March 15, 2005 (this “Agreement”), by and between INSMED INCORPORATED, a Virginia corporation (the “Company”), and (the “Investor”).

PURCHASE AGREEMENT dated as of March 15, 2005 by and between INSMED INCORPORATED and [NAME OF PURCHASER]
Purchase Agreement • March 16th, 2005 • Insmed Inc • Pharmaceutical preparations • New York

THIS PURCHASE AGREEMENT, dated as of March 15, 2005 (this “Agreement”), by and between INSMED INCORPORATED, a Virginia corporation (the “Company”), and [NAME OF PURCHASER] (the “Purchaser”).

AMENDMENT NO. 1 TO RIGHTS AGREEMENT
Rights Agreement • March 16th, 2005 • Insmed Inc • Pharmaceutical preparations

Amendment No. 1, dated as of March 15, 2005 (the “Amendment”), to the Rights Agreement, dated as of May 16, 2001 (the “Rights Agreement”), by and between Insmed Incorporated, a Virginia corporation (the “Company “), and Wachovia Bank, National Association (formerly known as First Union National Bank), a national banking association (the “Rights Agent”). Capitalized terms not defined herein shall have the meanings ascribed to them in the Rights Agreement.

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