0001193125-05-052738 Sample Contracts

NUVELO, INC. WARRANT TO PURCHASE SHARES OF COMMON STOCK
Nuvelo Inc • March 16th, 2005 • In vitro & in vivo diagnostic substances • California

This Warrant is issued to SAGAMORE HILL HUB FUND LTD., a Delaware limited partnership (“Holder” or the “Partnership”), by NUVELO, INC., a Nevada corporation (the “Company”), as of the date set forth beside the Company’s signature below, to replace lost warrant No. D-1, originally dated May 13, 2003 (the “Lost Warrant”).

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LEASE
Lease • March 16th, 2005 • Nuvelo Inc • In vitro & in vivo diagnostic substances • California

This LEASE (“Lease”) is made as of January 11, 2005 (“Effective Date”) between BMR-201 INDUSTRIAL ROAD LLC, a Delaware limited liability company (“Landlord”), and NUVELO, INC., a Delaware corporation (“Tenant”), who agree as follows:

LICENSE AGREEMENT BY AND BETWEEN AMGEN INC. AND NUVELO, INC.
License Agreement • March 16th, 2005 • Nuvelo Inc • In vitro & in vivo diagnostic substances • California

THIS LICENSE AGREEMENT (the “License Agreement”) is made effective as of November 3, 2004 (the “Effective Date”) by and between AMGEN INC., a Delaware corporation having its principal place of business at One Amgen Center Drive, Thousand Oaks, California 91320-1799 (“Amgen”) and NUVELO, INC., a Nevada corporation having its principal place of business at 670 Almanor Avenue, Sunnyvale, California 94085-1710 and formerly known as Hyseq, Inc. (“Nuvelo”). Amgen and Nuvelo are sometimes referred to herein individually as a “Party” and collectively as the “Parties”.

OPT-OUT, TERMINATION, SETTLEMENT AND RELEASE AGREEMENT
And Release Agreement • March 16th, 2005 • Nuvelo Inc • In vitro & in vivo diagnostic substances

THIS OPT-OUT, TERMINATION SETTLEMENT AND RELEASE AGREEMENT (the “Opt-Out Agreement”) is made effective as of October 29, 2004 (the “Effective Date”) by and between AMGEN INC., a Delaware corporation having its principal place of business at One Amgen Center Drive, Thousand Oaks, California 91320-1799 (“Amgen”) and NUVELO, INC., a Nevada corporation having its principal place of business at 670 Almanor Avenue, Sunnyvale, California 94085-1710 and formerly known as Hyseq, Inc. (“Nuvelo”). Amgen and Nuvelo are sometimes referred to herein individually as a “Party” and collectively as the “Parties”.

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