0001193125-05-166143 Sample Contracts

Amendment No. 1 to DEVELOPMENT AND LICENSE AGREEMENT
Development and License Agreement • August 12th, 2005 • Auxilium Pharmaceuticals Inc • Pharmaceutical preparations

THIS AMENDMENT NO. 1 TO THE DEVELOPMENT AND LICENSE AGREEMENT (“Amendment No. 1”) is entered into by and between Auxilium Pharmaceuticals, Inc., a company incorporated under the laws of Delaware with offices at 160 W. Germantown Pike, Norristown, PA 19401 and its Affiliate (collectively, “Auxilium”) and BioSpecifics Technologies Corp. a company organized and existing under the laws of the State of Delaware with offices located at 35 Wilbur Street, Lynbrook, New York 11563 and its Affiliates (collectively, “BTC”).

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RESEARCH AND DEVELOPMENT AGREEMENT
Research and Development Agreement • August 12th, 2005 • Auxilium Pharmaceuticals Inc • Pharmaceutical preparations • Delaware

THIS RESEARCH AND DEVELOPMENT AGREEMENT (this “Agreement”) is made as of the 24th day of February, 2005, by and between COBRA BIOLOGICS LTD (a wholly owned subsidiary of COBRA BIOMANUFACTURING Plc) (“COBRA”), located at The Science Park, Keele ST5 5SP, United Kingdom and AUXILIUM PHARMACEUTICALS, INC. with an office located at 160 W. Germantown Pike, Norristown, PA 19401 (“AUXILIUM”).

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