0001193125-05-188422 Sample Contracts

STOCKHOLDER AGREEMENT
Stockholder Agreement • September 20th, 2005 • Icoria, Inc. • Services-commercial physical & biological research • Delaware

THIS STOCKHOLDER AGREEMENT (this “Agreement”) is made and entered into as of September 19, 2005, by and among Clinical Data, Inc., a Delaware corporation (“Clinical Data”), Icoria, Inc., a Delaware corporation (“Icoria”), and the stockholders of Icoria identified in Schedule A hereto (each, a “Stockholder” and collectively, the “Stockholders”).

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SECOND AMENDMENT TO LOAN AND SECURITY AGREEMENT
Loan and Security Agreement • September 20th, 2005 • Icoria, Inc. • Services-commercial physical & biological research

THIS SECOND AMENDMENT TO LOAN AND SECURITY AGREEMENT (this “Amendment”) is entered into this 13th day of September, 2005, by and between SILICON VALLEY BANK (“Bank”) and ICORIA, INC., f/k/a PARADIGM GENETICS, INC., a Delaware corporation (“Borrower”) whose address is 108 T.W. Alexander Drive, Research Triangle Park, North Carolina 27709-4528.

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