0001193125-06-107485 Sample Contracts

Contract
Employment Agreement • May 10th, 2006 • Curagen Corp • Services-commercial physical & biological research • Connecticut

THIS EMPLOYMENT AGREEMENT (“Agreement”) is made and entered into as of March 29, 2006 between CuraGen Corporation, a corporation organized under the laws of the State of Delaware, with its principal place of business at 322 East Main Street, Branford, Connecticut (the “Company”), and Frank M. Armstrong, MD (“Executive”).

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To: Personnel File From: Elizabeth A. Whayland, SVP of Finance & Corporate Secretary Date: January 25, 2006 Re: Amendment to Employment Agreement dated May 20, 2002
Curagen Corp • May 10th, 2006 • Services-commercial physical & biological research

I, Elizabeth A. Whayland, (“the Executive”) signed an Employment Agreement (“the Agreement”) with my employer, CuraGen Corporation (“the Company”), on or about May 20, 2002, and subsequently signed an Addendum to the Agreement on October 31, 2003. Exhibit A, Item 1) of the original Agreement provides that the Executive’s initial base salary shall be subject to increases by the Board of Directors, which shall review the salary periodically. Therefore, pursuant to the minutes of the January 25, 2006, Meeting of the Compensation Committee of the Board of Directors, the Executive’s 2006 base salary will be adjusted to $211,000 per year, payable in bi-weekly installments.

To: Personnel File From: Christopher K. McLeod, President & CEO Date: January 25, 2006 Re: Amendment to Employment Agreement dated August 10, 2005
Curagen Corp • May 10th, 2006 • Services-commercial physical & biological research

I, Christopher K. McLeod, (“the Executive”) signed an Employment Agreement (“the Agreement”) with my employer, 454 Life Sciences Corporation (“the Company”), on or about August 10, 2005, and subsequently signed an Addendum to the Agreement on December 22, 2005. Schedule A, Item 1) of the original Agreement provides that the Executive’s initial base salary shall be subject to increases by the Board of Directors, which shall review the salary periodically. Therefore, pursuant to the minutes of the January 25, 2006, Meeting of the Compensation Committee of the Board of Directors, the Executive’s 2006 base salary will be adjusted to $338,000 per year, payable in bi-weekly installments.

To: Personnel File From: David M. Wurzer, EVP & Chief Financial Officer Date: January 25, 2006 Re: Amendment to Employment Agreement dated April 1, 2002
Curagen Corp • May 10th, 2006 • Services-commercial physical & biological research

I, David M. Wurzer, (“the Executive”) signed an Employment Agreement (“the Agreement”) with my employer, CuraGen Corporation (“the Company”), on or about April 1, 2002, and subsequently signed an Addendum to the Agreement on October 31, 2003. Exhibit A, Item 1) of the original Agreement provides that the Executive’s initial base salary shall be subject to increases by the Board of Directors, which shall review the salary periodically. Therefore, pursuant to the minutes of the January 25, 2006, Meeting of the Compensation Committee of the Board of Directors, the Executive’s 2006 base salary will be adjusted to $300,000 per year, payable in bi-weekly installments.

To: Personnel File From: Timothy M. Shannon, EVP & Chief Medical Officer Date: January 25, 2006 Re: Amendment to Employment Agreement dated September 9, 2002
Curagen Corp • May 10th, 2006 • Services-commercial physical & biological research

I, Timothy M. Shannon, (“the Executive”) signed an Employment Agreement (“the Agreement”) with my employer, CuraGen Corporation (“the Company”), on or about September 9, 2002, and subsequently signed an Addendum to the Agreement on October 31, 2003. Exhibit A, Item 1) of the original Agreement provides that the Executive’s initial base salary shall be subject to increases by the Board of Directors, which shall review the salary periodically. Therefore, pursuant to the minutes of the January 26, 2006, Meeting of the Compensation Committee of the Board of Directors, the Executive’s 2006 base salary will be adjusted to $325,000 per year, payable in bi-weekly installments.

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