0001193125-06-133731 Sample Contracts

REGISTRATION RIGHTS AGREEMENT
Registration Rights Agreement • June 22nd, 2006 • Ista Pharmaceuticals Inc • In vitro & in vivo diagnostic substances • New York

• broker-dealers may agree with the selling securityholders to sell a specified number of such shares at a stipulated price per share;

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SECURITIES PURCHASE AGREEMENT
Securities Purchase Agreement • June 22nd, 2006 • Ista Pharmaceuticals Inc • In vitro & in vivo diagnostic substances • New York

SECURITIES PURCHASE AGREEMENT (the “Agreement”), dated as of June 21, 2006, by and among ISTA Pharmaceuticals, Inc., a Delaware corporation, with headquarters located at 15295 Alton Parkway, Irvine, California 92618 (the “Company”), and the investors listed on the Schedule of Buyers attached hereto (individually, a “Buyer” and collectively, the “Buyers”).

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